Cell Physiology 512

Cellular Physiology - CELLPHYS512

Fall 2008

Michael Laskowski, PhD, Course Chair

(208) 885-6696 (WWAMI Idaho Office)

Room 320 Student Health Bldg

mlaskow@uidaho.edu

Gustavo Arrizabalaga, PhD

Assistant professor, MMBB

gustavo@uidaho.edu

Description - The focus of this course is on the physiology of excitable tissues. The monosynaptic stretch reflex is the thread that runs through the course, and will provide an orientation as we progress. We will examine how the properties of cell membranes lead to the establishment of a charge separation across the membrane. The charge separation can be used to create ionic currents by opening or closing protein-lined ion channels. These ionic currents can then be used to create a signal that can either be confined locally or transmitted long distances (up to 30 meters in a Blue whale). Nerves can influence other nerves by synaptic contact, and the synapses can be either electrical or chemical and either excitatory or inhibitory. Synapses are continually being modified, and such modification forms the basis of memory. Nerves also influence muscles. The nature of these influences will be examined along with the mechanisms by which the various types of muscles contract either spontaneously or in response to nerve or hormonal stimulation. Other forms of motility such as cytokinesis and axonal transport will be examined.

Additional topics will include the operation of the autonomic nervous system, sensory receptors, reflexes and the control of movement, as well as the transport of molecules and ions by gastrointestinal and renal epithelia.

Class requirements – You must complete this class to graduate from medical school. You cannot enroll in a summer program such as RUOP until this class is completed. The material presented in this class is essential to understanding what follows in several second year modules such as Nervous System, Cardiovascular, Respiratory, and Pharmacology. An understanding of physiological principles forms the basis for the rational practice of medicine. This class contains a significant amount of clinical material that is largely explained by basic physiology.

Exams - There will be three multiple choice exams each of equal weight. An overall grade of 70% is passing. Anyone scoring below 75% on the first exam must meet with the course instructors. A second exam will be given toward the end of the course. The final exam will be given in December and will consist of a 50 question multiple choice “Common Exam” that is comprehensive. Students must score an average of 70% or above on the Common Exam to pass the class.

Disability – If you are disabled, let us know and we will make every effort to accommodate you.

Class attendance – Attendance in class is not required. Clinical material will be presented, and this information is generally not readily obtained elsewhere.

Textbooks – Although no textbook is required, we recommend Medical Physiology, Second Edition by R.A. Rhoades and G.A. Tanner. Sufficient copies should be available in the bookstore. The sixth edition of Physiology by Berne and Levy is also a good text. Review of Medical Physiology by Ganong, A.C. Guyton’s texts as well as Kandel’s Principles of Neural Science are all good books. Make sure you use an edition that is no more than a few years old since the field is rapidly changing.

Challenging out - The material in this course is unlike most Cell Physiology courses offered elsewhere. If you want to try to challenge out of the class, please see the course chair.

Instructors – All instructors are housed on the UI Campus. Mike Laskowski’s office is across from the WWAMI Office at UI (mlaskow@uidaho.edu). Gustavo Arrizabalaga’s office is 145 Life Science (same building as the Histo Lab). gustavo@uidaho.edu.

How to study – The best way to study is to keep up with the lecture material and attend class. If you do not understand something, then ask or e-mail the instructor. If you get behind and are postponing the understanding of key concepts, then lectures will become less valuable.

Required Statement on Misconduct – All forms of academic misconduct such as cheating on exams or obtaining inappropriate test information from other WWAMI sites are considered inappropriate. Please do not jeopardize your future by engaging in such activities. If you are uncertain whether something is inappropriate, please ask us first.

Links to HuBio512 at the University of Washington – You may wish to follow the course at the University of Washington through the following links:

Main Page:

https://courses.washington.edu/hubio512/index.html

Powerpoints:

https://courses.washington.edu/hubio512/schedule.html

Syllabus as pdf (by chapter)

https://courses.washington.edu/hubio512/schedule.html

Cell Physiology Course Outline Fall 2008

Cell Physiology Course Outline Fall 2008 (8/24/08)

Week	Session	Date	Time	Topic	Lecturer
1	1 2 3	Aug 21	1:10 2:10 3:10	Introduction Cell Membranes Cell Membranes	ML ML ML
	3	Aug 22	9:10	Excitability	ML
2	5 6 7	Aug 28	1:10 2:10 3:10	Excitability Excitability Excitability	ML ML ML
	8	Aug 29	9:10	Excitability	ML
3	9 10 11	Sept 4	1:10 2:10 3:10	Excitability Sensory Receptors Sensory receptors	ML ML ML
	12	Sept 5	9:10	Sensory Receptors	ML
4	13 14 15	Sept 11	1:10 2:10 3:10	Sensory Receptors Sensory Receptors Neuromuscular Junction	ML ML ML
	16	Sept 12	9:10	Neuromuscular Junction	ML
5	17 18 19 20	Sept 18	8:10 1:10 2:10 3:10	Neuromuscular Junction Excitatory Transmission Excitatory Transmission Excitatory Transmission	ML ML ML ML
6	21 22 23	Sept 25	1:10 2:10 3:10	Inhibitory Transmission CNS Transmitters Review	ML ML ML
	23	Sept 26	9:10	Review	ML
7		Oct 3	1:10	Exam #1	ML
8	24 25 26	Oct 9	1:10 2:10 3:10	Signal Transduction Autonomic NS Autonomic NS	GA GA GA
9	27 28 29	Oct 16	1:10 2:10 3:10	Autonomic reflexes Skeletal Muscle Skeletal Muscle	GA GA GA
10	30 31 32	Oct 23	1:10 2:10 3:10	Skeletal Muscle Cardiac Muscle Cardiac Muscle	GA GA GA
10	33 34	Oct 24	8:10 9:10	Cardiac Muscle Smooth Muscle	GA GA
11	35 36 37	Oct 30	1:10 2:10 3:10	Smooth Muscle Smooth Muscle Non-muscle Motility	GA GA GA
	38	Oct 31	9:10	TBA	GA
12	39 40 41 42	Nov 6	8:10 1:10 2:10 3:10	Motor Units Motor Units Reflexes and Movement Reflexes and Movement	ML ML ML ML
13	43 44 45	Nov 13	1:10 2:10 3:10	Reflexes and Movement Epithelial Transport Epithelial Transport	ML ML ML
	46 47	Nov 14	8:10 9:10	Epithelial Transport Systems Physiology	ML ML
14	48 49 50	Nov 20	1:10 2:10 3:10	Review Review Review	ML ML GA
15	Thanksgiving Break
16		Dec 2	9:10	Exam #2	GA,ML
18		Dec 16	1:10	Final Exam	GA,ML